Threat of Hepatic and Renal Toxicity in Patients with Chronic Suppurative Otitis Media and Possible Drug Response

Abstract

Objective: To assess the jeopardy of hepatic and renal toxicity in patients suffering from chronic suppurative otitis media and possible drug’s response to treat the condition.

Methodology: This was a case control trial that was conducted in patients with chronic suppurative otitis media reported to ENT OPD of Khalifa Gul Nawaz teaching hospital Bannu-KP. The duration of the study was from August 2021 to February 2021. Sample size was 160, that was calculated using WHO calculator. Sixty volunteers were included in the study. Negative control group, positive control group, patients treated with Co-amoxiclave, and patients treated with Ciprofloxacin, patients and healthy volunteers were  randomized into four groups.

Results: The results of the study showed a significant increase in direct bilirubin levels, total bilirubin levels, SGPT, GGT and alkaline phosphatase in positive control group in comparison to negative control. The treated groups with antibiotics remained successful in recovering normal liver enzymes excepting SGPT and direct bilirubin. Blood glucose and urea was found to be insignificant in G2 and G3 groups whereas in G4 group, an increased creatinine was seen which was statistically insignificant. 

Conclusion: Our study concluded that in patients suffering from chronic suppurative otitis media, hepatic toxicity might be induced if remained untreated. It is therefore, proper treatment with follow-up is required in these patients.