The Role of Hypoglycaemic Agent; Dipeptidyl Peptidase–4 and Its Relation with Biochemical Parameters in Patients With Type–2 Diabetes: A Three Months Trial

Abstract

Objective: This study was undertaken in order to find out the hypoglycemic control of DPP–4 on the diabetic patients and to evaluate the other related problems.

Methodology: A total of 320 type 2 diabetes patients were included in this study. They were treated with oral hypoglycemic drugs. Random  as well as fasting blood samples were taken in all hygienic conditions. HbA1c, RBS, FBS, RFTs, serum electrolytes and lipid profiling was carried out by colorimetric methods using kits on Macro Lab 200. The kits were obtained from Elitech, Spain. Fried Wald’s formula was used to determine LDL–c.

Results: FBS, HbA1C and urea were significantly different (p < 0.05) when compared with base line data while opposite results (p > 0.05) were obtained for RBS, serum total cholesterol, creatinine and TG and serum electrolytes.

Conclusion: Risk factors related to diabetes can be reduced by using anti–hyperglycemic agents (DPP–4) on regular basis for a period of three months or more.