Frequency of Mortality in Cirrhotic Patients with Spontaneous Bacterial Peritonitis having Model for End Stage Liver Disease (MELD) Score >22

Authors

  • Faizan Ali Memon Registrar Asian Institute of Medical Sciences Hyderabad
  • Prem Kumar Assistant Professor of Medicine Isra University Hospital Hyderabad, Sindh
  • Doulat Singh Sodho Associate Professor Department of Medicine Indus Medical College Tando Mohammad Khan
  • Sunil Dat Maheshwari Assistant Professor of Medicine Department of Medicine Isra University Hospital, Hyderabad
  • Shabnam Rani Assistant Professor Department of Medicine Muhammad Medical and Dental College Mirpur Khas, Sindh
  • Falak Naz Consultant gastroenterologist & hepatologist Hashim Medical City Hospital, Hyderabad

Keywords:

Cirrhosis, Spontaneous bacterial peritonitis, MELD score, Ascites, Infection

Abstract

Objective: To determine the frequency of mortality in cirrhotic patients with spontaneous bacterial peritonitis having Model for end stage liver disease (MELD) score >22.

Methodology: This was a hospital based prospective clinical study conducted at the department of gastroenterology & hepatology, Isra University Hospital, Hyderabad. Patients diagnosed cases of CTP class B & C liver cirrhosis and having age more than 40 years to 60 years with MELD score >22 were included. Patients with who do not consent and those who had underlying hepatocellular carcinoma were excluded from this study. The descriptive frequencies and percentages were computed for gender, education level, economic status, and mortality. Age, duration of disease, and MELD score were calculated and presented as Mean±SD.

Results: Most of the patients belongs to middle age group (Mean±SD was 51.95±5.77 years). Mean ± SD MELD score was 27.67 ± 4.04 mg/dL. Males patients were 52.78% (n= 57). Among 108 admitted patients of SBP, 33 patients with MELD score >22 did not survive, thus mortality rate was 30.56% with significant association (p value < 0.003) while insignificant association was observed in respect to age, gender, economic status, and duration of illness with MELD score >22.

Conclusion: Due to the higher prevalence of chronic hepatitis C in our population, there is an abundance of cirrhosis patients. Spontaneous bacterial peritonitis is quite common in cirrhosis patients in our population. Non-invasive scoring system (MELD) is quite useful in assessing the prognosis of patients with liver cirrhosis and SBP.

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Published

2023-01-08

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Original Articles