Antimicrobial Resistance Pattern of Pseudomonas Aeruginosa Specie in Patients of Shaikh Zayed Hospital Lahore Pakistan

Abstract

Background: Pseudomonas aeruginosa is gram negative rod, motile, and an aerobic bacterium. It is the leading cause of opportunistic Nosocomial infections. It is a typical pathogen correlated with respiratory tract infections, cystic fibrotic patients and is also the causative of pseudomonal pneumonia.

Material and Methods: Present retrospective hospital record based cross sectional analytical study included a total of 2680 clinical samples was compile from patients of Shaikh Zayed Hospital, Lahore Pakistan from January 2013 to December 2014. Samples were processed and identified by standard protocol. The P. aeruginosa was tested for antibiotic resistance by Kirby Bauer disc method according to CLSI guidelines.

Results Three groups which are described in detail, as a result of studying among the 200 isolated Pseudomonas aeruginosa the following antibiotics was used i.e. IPM, MEM, AK, CN, CIP, CAZ, SCF and TZP. We finally came to a conclusion that IPM, MEM, CAZ, SCF, TZP are having less resistivity and more sensitivity, and the AK, CN, CIP is more resistant while the sensitivity is less. The percentage detail for resistivity in IPM was 33%, MEM was 29%, CAZ was 45%, SCF was 40.5%, the TZP was 40.5%, AK was 51.5%, CN was 64%, and the CIP was 58%.

Conclusion: This hospital based epidemiological data will help to follow better infection control strategies and improve the knowledge of antibiotic resistance patterns among clinicians. Thus there is a need for antimicrobial surveillance to monitor the resistance patterns in local hospitals.